GLP-1 Weight Loss Timeline: A Month-by-Month Guide
Weight loss isn't linear. Here is a realistic look at what happens to your body during the first 6 months on GLP-1 therapy.
The Titration Phase
Most GLP-1 medications require a "titration" period—starting at a low dose and increasing monthly to minimize side effects. This means huge weight loss usually doesn't happen in Week 1.
Month 1: The Adjustment
Focus: Getting used to the medication.
- Dose: Typically the lowest starting dose (e.g., 0.25mg Semaglutide).
- Weight Loss: Minimal to moderate (2-4 lbs). Much of this may be water weight as inflammation decreases.
- Feeling: You may notice "food noise" getting quieter. Mild nausea is common.
Month 2-3: The Acceleration
Focus: Stepping up the dose.
- Dose: Increasing to therapeutic levels.
- Weight Loss: Rate increases (1-2 lbs per week is healthy).
- Feeling: Appetite suppression becomes consistent. You get full much faster.
Month 6: The "New You"
Focus: Stabilization and body composition.
By month 6, many patients on Semaglutide have lost ~10% of their body weight, and those on Tirzepatide may have lost even more. This is often where friends and family start to comment on the visual changes.
Your Personal Timeline
Every body responds differently. While averages are helpful, seeing your specific projection based on your starting weight is more powerful.