How the Wegovy Weight Loss Calculator Works
Our Wegovy calculator uses a compounding weight loss model derived from the STEP-1 clinical trial — the landmark study of semaglutide 2.4mg published in the New England Journal of Medicine. In this 68-week trial, participants lost an average of 14.9% of their body weight compared to 2.4% with placebo.
Wegovy (semaglutide) is the FDA-approved weight management version of the same drug in Ozempic, but at a higher maximum dose (2.4mg vs 2mg). This calculator models the typical non-linear weight loss pattern: gradual loss during dose titration, peak loss between months 3-8, then a plateau as your body reaches equilibrium.
Wegovy Weight Loss by Starting Weight
Here's what the STEP-1 data suggests for Wegovy at different starting weights over 12 months:
| Starting Weight | Expected Loss (12 mo) | Projected Final Weight |
|---|---|---|
| 160 lbs | 20-28 lbs (12-17%) | 132-140 lbs |
| 180 lbs | 23-31 lbs (13-17%) | 149-157 lbs |
| 200 lbs | 26-34 lbs (13-17%) | 166-174 lbs |
| 220 lbs | 29-37 lbs (13-17%) | 183-191 lbs |
| 250 lbs | 33-43 lbs (13-17%) | 207-217 lbs |
| 300 lbs | 39-51 lbs (13-17%) | 249-261 lbs |
Wegovy Dosing Schedule
Wegovy follows a 16-week dose-escalation schedule to minimize GI side effects. Most weight loss occurs at the maintenance dose (2.4mg):
| Dose | Timeline | Purpose |
|---|---|---|
| 0.25 mg | Weeks 1-4 | Initiation dose |
| 0.5 mg | Weeks 5-8 | First escalation |
| 1.0 mg | Weeks 9-12 | Second escalation |
| 1.7 mg | Weeks 13-16 | Third escalation |
| 2.4 mg | Week 17+ | Maintenance dose — maximum weight loss |
Wegovy vs Ozempic: What's the Difference?
Both contain semaglutide, but they serve different purposes. Wegovy is FDA-approved specifically for chronic weight management and goes up to 2.4mg. Ozempic is approved for type 2 diabetes with a max dose of 2mg. Because Wegovy reaches a higher dose, it may produce slightly more weight loss in some patients.
Want to compare medications? Try our GLP-1 Weight Loss Calculator or the Mounjaro Calculator for tirzepatide projections.
What Does Wegovy Weight Loss Look Like?
Curious what 20-30 lbs of semaglutide weight loss actually looks like? Check our 20 Pound Weight Loss Visual Guide or see semaglutide before and after transformations.
Visualize Your Wegovy "After" Photo
Our AI simulates realistic weight loss effects based on semaglutide clinical data. Upload a photo to see exactly how your Wegovy results would look.
Related Resources
Medical Disclaimer: This calculator provides estimates based on average results from the STEP-1 clinical trial. Individual results vary significantly based on dosage, lifestyle, adherence, and biological factors. This tool is for informational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting any medication including Wegovy (semaglutide).